A., and Nicholson, G. C. Prevention and treatment of glucocorticoid-induced osteoporosis: a comparison of calcitriol, vitamin D plus calcium, and alendronate plus calcium. 2001;144(3):628-629. View abstract. View abstract. Garland CF, Gorham ED, Mohr SB, et al. Endocrinol Metab Clin North Am 2000;29:591-609. J Dent Res. Schleithoff SS, Zittermann A, Tenderich G, et al. View abstract. View abstract. Jorde, R., Figenschau, Y., Hutchinson, M., Emaus, N., and Grimnes, G. High serum 25-hydroxyvitamin D concentrations are associated with a favorable serum lipid profile. Jorde, R., Sneve, M., Torjesen, P., and Figenschau, Y. 2008;73(189):56477-87. Lind, L., Wengle, B., Lithell, H., and Ljunghall, S. No major metabolic alterations accompany the hypotensive effect of active vitamin D. Ups.J Med.Sci 1991;96(3):199-204. View abstract. 2007;17(9):663-668. Murad, M. H., Elamin, K. B., Abu Elnour, N. O., Elamin, M. B., Alkatib, A. [162], A review published in 2015 noted that adverse effects have been reported only at 25(OH)D serum concentrations above 200 nmol/L. J Steroid Biochem.Mol.Biol. Memmos, D. E., Eastwood, J. 1999;13(2):91-95. Treatment of osteopenia and osteoporosis after kidney transplantation. View abstract. Schoindre, Y., Terrier, B., Kahn, J. E., Saadoun, D., Souberbielle, J. C., Benveniste, O., Amoura, Z., Piette, J. C., Cacoub, P., and Costedoat-Chalumeau, N. [Vitamin D and autoimmunity. Jorde, R., Sneve, M., Figenschau, Y., Svartberg, J., and Waterloo, K. Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: randomized double blind trial. May 2012. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. 1997;17(6):505-510. View abstract. Rashidi, B., Haghollahi, F., Shariat, M., and Zayerii, F. The effects of calcium-vitamin D and metformin on polycystic ovary syndrome: a pilot study. A., Cosman, F., Lakatos, P., Leung, P. C., Man, Z., Mautalen, C., Mesenbrink, P., Hu, H., Caminis, J., Tong, K., Rosario-Jansen, T., Krasnow, J., Hue, T. F., Sellmeyer, D., Eriksen, E. F., and Cummings, S. R. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. 1989;191(3):287-292. Thacher, T. D., Fischer, P. R., Pettifor, J. M., Lawson, J. O., Isichei, C. O., and Chan, G. M. Case-control study of factors associated with nutritional rickets in Nigerian children. in names of dynasties, with the dynasty's founder as the base noun (Abbasid; Fatimid), and in names of periodic meteor showers, with the base noun usu. Taking vitamin D also does not seem to reduce the risk of a child catching tuberculosis. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. Arch Intern Med 1986;146:386-8. 2000;32(7):1876. Keum N, Lee DH, Greenwood DC, Manson JE, Giovannucci E. Vitamin D supplementation and total cancer incidence and mortality: a meta-analysis of randomized controlled trials. Trop.Med.Int Health 2011;16(6):699-706. Acta Derm.Venereol. Boonen S, Body JJ, Boutsen Y, et al. View abstract. View abstract. View abstract. 2009;(4):CD007298. Medicine (Baltimore). 2019;98(14):e14970. J Ren Nutr 2003;13(2):78-83. 8-20-2009;361(8):745-755. Clin J Am Soc Nephrol. 1984;8(5):407-411. Avoid taking vitamin D supplements if you are taking calcipotriene (Dovonex). 2019;366:l4673. 2011;(7):CD007470. Karkkainen, M. K., Tuppurainen, M., Salovaara, K., Sandini, L., Rikkonen, T., Sirola, J., Honkanen, R., Arokoski, J., Alhava, E., and Kroger, H. Does daily vitamin D 800 IU and calcium 1000 mg supplementation decrease the risk of falling in ambulatory women aged 65-71 years? New 2010 Vitamin D Recommendations. View abstract. The best evidence to date shows that vitamin D does not reduce the risk of falling in elderly people. View abstract. Trager, J. D. What's your diagnosis? Tenconi, M. T., Devoti, G., Comelli, M., Pinon, M., Capocchiano, A., Calcaterra, V., and Pretti, G. Major childhood infectious diseases and other determinants associated with type 1 diabetes: a case-control study. Int J Urol. Heart failure. View abstract. View abstract. View abstract. Thomsen, K., Riis, B., and Christiansen, C. Effect of estrogen/gestagen and 24R,25-dihydroxyvitamin D3 therapy on bone formation in postmenopausal women. View abstract. Horm Metab Res. 2007;100(4):185-192. [165][168] Land vertebrates have been photosynthesizing vitamin D for more than 350 million years. View abstract. Saraceno, R., Andreassi, L., Ayala, F., Bongiorno, M. R., Giannetti, A., Lisi, P., Martini, P., Peris, K., Peserico, A., and Chimenti, S. Efficacy, safety and quality of life of calcipotriol/betamethasone dipropionate (Dovobet) versus calcipotriol (Daivonex) in the treatment of psoriasis vulgaris: a randomized, multicentre, clinical trial. Cochrane Database Syst Rev 2006;(4):CD001880. [102] Although taking vitamin D supplements during pregnancy raises blood levels of vitamin D in the mother at term,[103] the full extent of benefits for the mother or baby is unclear. Bone Miner. View abstract. X-ray crystallography demonstrated the sterol molecules were flat, not as proposed by the German team led by Windaus. Early research suggests that giving vitamin D supplements to infants daily during the first year of life is linked to a lower risk of developing type 1 diabetes later in life. Arthur, R. S., Piraino, B., Candib, D., Cooperstein, L., Chen, T., West, C., and Puschett, J. Shearer MJ. View abstract. Taking vitamin D along with digoxin (Lanoxin) might increase the effects of digoxin (Lanoxin) and lead to an irregular heartbeat. BMJ. View abstract. View abstract. Pettila V, Leinonen P, Markkola A, et al. 1988;1(4 Pt 1):397-402. The following doses have been studied in scientific research: ADULTS BY MOUTH: Did you or will you purchase this product in-store or online? Cancer Epidemiol Biomarkers Prev. BMJ 2005;330:1003. Piura E, Chapman JW Lipton A et al. Annweiler, C. and Beauchet, O. O'Donnell, S., Moher, D., Thomas, K., Hanley, D. A., and Cranney, A. View abstract. Nephrology.(Carlton.) Toner, C. D., Davis, C. D., and Milner, J. Diltiazem (Cardizem, Dilacor, Tiazac) interacts with VITAMIN D. Vitamin D helps your body absorb calcium. Bjelakovic G, Gluud LL, Nikolova D, et al. 2007;5(6):467-475. 2006;21(3):350-354. Early research shows that taking vitamin D long-term can reduce the risk of developing MS in women by up to 40%. High doses of vitamin D to reduce exacerbations in chronic obstructive pulmonary disease: a randomized trial. Michaelson, M. D., Kaufman, D. S., Lee, H., McGovern, F. J., Kantoff, P. W., Fallon, M. A., Finkelstein, J. S., and Smith, M. R. Randomized controlled trial of annual zoledronic acid to prevent gonadotropin-releasing hormone agonist-induced bone loss in men with prostate cancer. N Engl J Med 1999;340:101-7. Age Ageing 2007;36(5):507-513. Iwasaki, T., Takei, K., Nakamura, S., Hosoda, N., Yokota, Y., and Ishii, M. Secondary osteoporosis in long-term bedridden patients with cerebral palsy. Pathak K, Soares MJ, Calton EK, Zhao Y, Hallett J. Vitamin D supplementation and body weight status: a systematic review and meta-analysis of randomized controlled trials. [201] One meta-analysis found a decrease in mortality in elderly people. View abstract. 11-1-1990;113(9):649-655. View abstract. Int J Clin.Pract. Mannion, C. A., Gray-Donald, K., and Koski, K. G. Association of low intake of milk and vitamin D during pregnancy with decreased birth weight. View abstract. View abstract. [210] A number of trials in different countries are being carried out in 2020 to address the potential for the use of vitamin D for the prevention and treatment of SARS-CoV-2 infections. Bischoff-Ferrari HA, Borchers M, Gudat F, et al. A randomized controlled trial. Ravn, P., Clemmesen, B., Riis, B. J., and Christiansen, C. The effect on bone mass and bone markers of different doses of ibandronate: a new bisphosphonate for prevention and treatment of postmenopausal osteoporosis: a 1-year, randomized, double-blind, placebo-controlled dose-finding study. 5-10-2010;170(9):813-820. View abstract. The Effect of Vitamin D Supplementation on Prostate Cancer: A Systematic Review and Meta-Analysis of Clinical Trials. Pitt, P., Li, F., Todd, P., Webber, D., Pack, S., and Moniz, C. A double blind placebo controlled study to determine the effects of intermittent cyclical etidronate on bone mineral density in patients on long-term oral corticosteroid treatment. Does inconclusive evidence for vitamin D supplementation to reduce risk for cardiovascular disease warrant pessimism? But limited research in children shows that taking one large dose of vitamin D doesn't prevent pneumonia or make it less severe. View abstract. Compston JE, Horton LW. Bischoff-Ferrari, H. A., Dawson-Hughes, B., Baron, J. Autier P, Gandini S. Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. [48] Osteomalacia reduces calcium absorption and increases calcium loss from bone, which increases the risk for bone fractures. Am J Clin Nutr 2008;87(6):1738-1742. These drugs include enoxaparin (Lovenox), dalteparin (Fragmin), and tinzaparin (Innohep). B., Feskanich, D., and Willett, W. C. Milk intake and risk of hip fracture in men and women: a meta-analysis of prospective cohort studies. ", "Adequate calcium and regular exercise may help to achieve strong bones in children and adolescents and may reduce the risk of osteoporosis in older adults. Some factors of diet influencing the spread of caries in children. Fang F, Ni K, Cai Y, Shang J, Zhang X, Xiong C. Effect of vitamin D supplementation on polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Coco, M., Glicklich, D., Faugere, M. C., Burris, L., Bognar, I., Durkin, P., Tellis, V., Greenstein, S., Schechner, R., Figueroa, K., McDonough, P., Wang, G., and Malluche, H. Prevention of bone loss in renal transplant recipients: a prospective, randomized trial of intravenous pamidronate. Fernandes, J. L., Viana, S. L., Rocha, A. L., Ribeiro, M. C., and Castro, L. C. Biphosphonate-induced radiographic changes in two pediatric patients with rheumatic diseases. View abstract. Salusky, I. View abstract. 1941;62:1183-1187. Controlled trial of calcitriol in hemodialysis patients. 1. Przedlacki, J., Manelius, J., and Huttunen, K. Bone mineral density evaluated by dual-energy X-ray absorptiometry after one-year treatment with calcitriol started in the predialysis phase of chronic renal failure. Demontis R, Reissi D, Noel C, et al. Neurology 6-8-2010;74(23):1852-1859. Bartley, J. Bonakdaran, S., Ayatollahi, H., Mojahedi, M. J., Sharifipoor, F., and Shakeri, M. Impact of treatment with oral calcitriol on glucose intolerance and dyslipidemia(s) in hemodialysis patients. Vol. Zhonghua Yi Xue Za Zhi 5-15-2012;92(18):1268-1271. A two-compound product containing calipotriol and betamethasone dipropionate provides rapid, effective treatment of psoriasis vulgaris regardless of baseline disease severity. J Clin Endocrinol Metab. View abstract. McClung, M. R., Lewiecki, E. M., Cohen, S. B., Bolognese, M. A., Woodson, G. C., Moffett, A. H., Peacock, M., Miller, P. D., Lederman, S. N., Chesnut, C. H., Lain, D., Kivitz, A. J., Holloway, D. L., Zhang, C., Peterson, M. C., and Bekker, P. J. Denosumab in postmenopausal women with low bone mineral density. 4-24-2006;166(8):869-875. View abstract. 2017;65(10):2161-2168. View abstract. Hopkins, B. and Steward, D. Outpatient thyroid surgery and the advances making it possible. Well-demarcated vulvar erythema in two girls. Arthritis Rheum. [158], Synthesis of vitamin D in nature is dependent on the presence of UV radiation and subsequent activation in the liver and in the kidneys. View abstract. 2008;108(9):1472-1479. Diabetologia 2009;52(12):2542-2550. J Bone Miner Metab 2004;22(1):32-38. Meier, C., Woitge, H. W., Witte, K., Lemmer, B., and Seibel, M. J. Supplementation with oral vitamin D3 and calcium during winter prevents seasonal bone loss: a randomized controlled open-label prospective trial. View abstract. View abstract. View abstract. Osteoporos.Int 2011;22(3):859-871. A longitudinal study. Ryan, C. W., Huo, D., Demers, L. M., Beer, T. M., and Lacerna, L. V. Zoledronic acid initiated during the first year of androgen deprivation therapy increases bone mineral density in patients with prostate cancer. Gallacher, S. J., McQuillian, C., Harkness, M., Finlay, F., Gallagher, A. P., and Dixon, T. Prevalence of vitamin D inadequacy in Scottish adults with non-vertebral fragility fractures. View abstract. [200] In their 2020 update it was recognized that a growing body of research suggests that vitamin D might play some role in the prevention and treatment of types 1 and 2 diabetes, glucose intolerance, hypertension, multiple sclerosis, and other medical conditions. Incidence of dental caries in school children as a function of light quality and radiation shielding. Noguera, A., Ros, J. View abstract. Przegl.Lek. Grozdev, I. S., Van Voorhees, A. S., Gottlieb, A. View abstract. J Lab Clin.Med. Thacher TD, Ighogboja SI, and Fischer PR. 2007;178(4 Pt 1):1497-1503. McAlindon, T., LaValley, M., Schneider, E., Nuite, M., Lee, J. Y., Price, L. L., Lo, G., and Dawson-Hughes, B. The Institute found serum 25(OH)D concentrations above 30 ng/mL (75 nmol/L) are "not consistently associated with increased benefit". [166][167] First, 7-dehydrocholesterol is photolyzed by ultraviolet light in a 6-electron conrotatory ring-opening electrocyclic reaction; the product is previtamin D3. Ishida, Y. and Kawai, S. Comparative efficacy of hormone replacement therapy, etidronate, calcitonin, alfacalcidol, and vitamin K in postmenopausal women with osteoporosis: The Yamaguchi Osteoporosis Prevention Study. 2003;35(4):1393-1395. 1999. Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC, et al. Effect of Vitamin D supplementation on relapse-free survival among patients with digestive tract cancers: The AMATERASU randomized clinical trial. A high-level overview of Dominion Energy, Inc. (D) stock. Li, X., Liao, L., Yan, X., Huang, G., Lin, J., Lei, M., Wang, X., and Zhou, Z. BMC.Public Health 2010;10:331. Papapoulos, S. E., Quandt, S. A., Liberman, U. Diabetes Care 2007;30(4):980-986. Cesur, Y., Dogan, M., Ariyuca, S., Basaranoglu, M., Bektas, M. S., Peker, E., Akbayram, S., and Caksen, H. Evaluation of children with nutritional rickets. Cimetidine (Tagamet) interacts with VITAMIN D. The body changes vitamin D into a form that it can use. [125], The European Food Safety Authority (EFSA) in 2016[119] reviewed the current evidence, finding the relationship between serum 25(OH)D concentration and musculoskeletal health outcomes is widely variable. [153], Published cases of toxicity involving hypercalcemia in which the vitamin D dose and the 25-hydroxy-vitamin D levels are known all involve an intake of ≥40,000 IU (1,000 μg) per day. Kukuljan, S., Nowson, C. A., Bass, S. L., Sanders, K., Nicholson, G. C., Seibel, M. J., Salmon, J., and Daly, R. M. Effects of a multi-component exercise program and calcium-vitamin-D3-fortified milk on bone mineral density in older men: a randomised controlled trial. Williams SE, Wardman AG, Taylor GA, et al. View abstract. [207] Both organizations included recommendations to continue the previous established recommendations on vitamin D supplementation for other reasons, such as bone and muscle health, as applicable. View abstract. Ann.Intern.Med. Low serum 25 (OH) vitamin D levels (<32 ng/mL) are associated with reversible myositis-myalgia in statin-treated patients. 2010;69(8):1448-1452. Urology 2002;60(3):79-85. Transplant.Proc. Bolland, M. J., Grey, A., Avenell, A., Gamble, G. D., and Reid, I. R. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. Diabetologia 2010;53(10):2112-2119. J Dermatol 2005;32(6):420-423. Research about the effects of vitamin D on osteoarthritis is conflicting. (check all that apply), What factors are most important to you? (Full.Rep) 2009;(183):1-420. Effects of vitamin D supplementation on strength, physical function, and health perception in older, community-dwelling men. Curr.Med.Res Opin. Neurology 2004;62:60-5. . View abstract. J Dent Res. View abstract. View abstract. View abstract. J Am Geriatr Soc 1990;38(8):862-866. A systematic review and meta-analysis of randomized trials. View abstract. Carlin, A. M., Rao, D. S., Yager, K. M., Parikh, N. J., and Kapke, A. Bolland MJ, Grey A, Gamble GD, Reid IR. View abstract. Maturitas 2004;49:334-7. Corless, D., Dawson, E., Fraser, F., Ellis, M., Evans, S. J., Perry, J. D., Reisner, C., Silver, C. P., Beer, M., Boucher, B. J., and . View abstract. View abstract. The most reliable research shows that giving vitamin D to people with low vitamin D levels who are in the hospital with a critical illness does not make them more likely to live. Transplant.Proc. Dequeker, J., Borghs, H., Van, Cleemput J., Nevens, F., Verleden, G., and Nijs, J. Transplantation osteoporosis and corticosteroid-induced osteoporosis in autoimmune diseases: experience with alfacalcidol. View abstract. B. Narrow-band UVB311 nm vs. broad-band UVB therapy in combination with topical calcipotriol vs. placebo in vitiligo. Nguyen, N. D., Eisman, J. Coburn JW. Daniel, D. and Pirotta, M. V. Fibromyalgia--should we be testing and treating for vitamin D deficiency? Health Technol Assess. Orimo, H., Shiraki, M., Hayashi, T., and Nakamura, T. Reduced occurrence of vertebral crush fractures in senile osteoporosis treated with 1 alpha (OH)-vitamin D3. J Bone Miner Metab 2008;26(6):531-542. Weiner M, Epstein FH. LaCroix, A. Ruiz-Irastorza, G., Ramos-Casals, M., Brito-Zeron, P., and Khamashta, M. A. Am J Clin Nutr 2010;91:1255-60. Prince, R. L., Devine, A., Dhaliwal, S. S., and Dick, I. M. Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double-blind, placebo-controlled trial in elderly women. Lancet Diabetes Endocrinol. Acta Paediatr. Relationship between bone, fracture, and exercise: the key role of vitamin D. Arch Intern Med 9-28-2009;169(17):1638. Erratum in: JAMA. Ann Rheum Dis 2000;59:742. View abstract. Chapuy MC, Arlot ME, Duboeuf F, et al. The effect of fluoride and calcium on spinal bone mineral content: a controlled, prospective (3 years) study. Clin Exp.Dermatol 1993;18(6):504-506. View abstract. J Am Acad Dermatol 1995;32(1):67-72. J Bone Miner Res 1989;4(1):81-88. Baker, L. R., Abrams, L., Roe, C. J., Faugere, M. C., Fanti, P., Subayti, Y., and Malluche, H. H. 1,25(OH)2D3 administration in moderate renal failure: a prospective double-blind trial. Search the world's information, including webpages, images, videos and more. J Clin Endocrinol Metab. View abstract. Am J Clin Nutr. Boutsen, Y., Jamart, J., Esselinckx, W., Stoffel, M., and Devogelaer, J. P. 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